Department of Biotechnology & Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, India.
Infect Genet Evol. 2012 Dec;12(8):1647-51. doi: 10.1016/j.meegid.2012.08.002. Epub 2012 Aug 13.
Diarrhea occurs world-wide and is most commonly caused by gastrointestinal infections which kill around 2.2 million people globally each year, mostly children in developing countries. We describe here dbDiarrhea, which is currently the most comprehensive catalog of proteins implicated in the pathogenesis of diarrhea caused by major bacterial, viral and parasitic species. The current release of the database houses 820 proteins gleaned through an extensive and critical survey of research articles from PubMed. The major contributors to this compendium of proteins are Escherichia coli and Salmonella enterica. These proteins are classified into different categories such as Type III secretion system effectors, Type III secretion system components, and Pathogen proteins. There is another complementary module called 'Host proteins'. dbDiarrhea also serves as a repository of the research articles describing (1) trials of subunit and whole organism vaccines (2) high-throughput screening of Type III secretion system inhibitors and (3) diagnostic assays, for various diarrheal pathogens. The database is web accessible through an intuitive user interface that allows querying proteins and research articles for different organism, keywords and accession number. Besides providing the search facility through browsing, the database supports sequence similarity search with the BLAST tool. With the rapidly burgeoning global burden of the diarrhea, we anticipate that this database would serve as a source of useful information for furthering research on diarrhea. The database can be freely accessed at http://www.juit.ac.in/attachments/dbdiarrhea/diarrhea_home.html.
腹泻在全球范围内都很常见，通常是由胃肠道感染引起的，每年在全球范围内导致约 220 万人死亡，其中大多数是发展中国家的儿童。我们在这里描述 dbDiarrhea，它是目前涉及主要细菌、病毒和寄生虫引起腹泻的发病机制的蛋白质的最全面目录。该数据库的当前版本收录了 820 种蛋白质，这些蛋白质是通过对来自 PubMed 的研究文章进行广泛而严格的调查而获得的。本蛋白质汇编的主要贡献者是大肠杆菌和沙门氏菌。这些蛋白质分为不同的类别，如 III 型分泌系统效应子、III 型分泌系统组件和病原体蛋白。还有另一个名为“宿主蛋白”的补充模块。dbDiarrhea 还是描述（1）亚单位和全生物体疫苗试验、（2）III 型分泌系统抑制剂高通量筛选和（3）各种腹泻病原体诊断检测的研究文章的存储库。该数据库通过直观的用户界面提供网络访问，允许根据不同的生物体、关键字和访问号查询蛋白质和研究文章。除了通过浏览提供搜索功能外，该数据库还支持使用 BLAST 工具进行序列相似性搜索。随着腹泻在全球范围内的负担迅速增加，我们预计该数据库将成为进一步研究腹泻的有用信息来源。该数据库可免费访问，网址为 http://www.juit.ac.in/attachments/dbdiarrhea/diarrhea_home.html。
