人类嗜 T 淋巴细胞病毒 1 型感染：哪些因素决定了炎症性疾病的风险？

HTLV-1 infection: what determines the risk of inflammatory disease?

机构信息

Imperial College London, Department of Immunology, Norfolk Place, London W2 1PG, UK.

出版信息

Trends Microbiol. 2012 Oct;20(10):494-500. doi: 10.1016/j.tim.2012.07.004. Epub 2012 Aug 21.

DOI:10.1016/j.tim.2012.07.004

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) is an exogenous retrovirus that persists lifelong in the infected host. Infection has been linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predisposition to opportunistic bacterial and helminth infections. Applications of new technologies and biological concepts to the field have provided new insights into viral persistence and pathogenesis in HTLV-1 infection. Here, we summarize the emerging concepts of dynamic HTLV-1-host interactions and propose that chronic interferon (IFN) production causes tissue damage in HTLV-1-associated inflammatory diseases.

摘要

人类 T 淋巴细胞白血病病毒 1 型（HTLV-1）是一种外源性逆转录病毒，在受感染的宿主中终身存在。该病毒感染与一系列不同的疾病有关：成人 T 细胞白血病、脑脊髓病和易发生机会性细菌和寄生虫感染的倾向。新技术和生物学概念在该领域的应用为 HTLV-1 感染中的病毒持续存在和发病机制提供了新的见解。在这里，我们总结了 HTLV-1 宿主相互作用的动态新概念，并提出慢性干扰素（IFN）产生导致 HTLV-1 相关炎症性疾病中的组织损伤。