Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL 33136, USA.
Int J Dermatol. 2011 Aug;50(8):915-20. doi: 10.1111/j.1365-4632.2011.04882.x.
Human T-lymphotropic virus type 1 (HTLV-1) is a type C retrovirus primarily endemic to Japan, Central and South America, the Middle East, regions of Africa, and the Caribbean. Currently, an estimated 10-20 million people worldwide are infected with this virus. Although the majority of infected individuals remain asymptomatic, HTLV-1 is the causative agent of a number of disorders, notably adult T-cell leukemia/lymphoma (ATLL) and a progressive demyelinating neurological disorder, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to ATLL and HAM/TSP, HTLV-1 has been associated with a spectrum of skin disorders, such as infective dermatitis associated with HTLV-1, crusted scabies, and leprosy. The understanding of the interaction between virus and host response has improved markedly, but there are still few treatment options.
人类 T 淋巴细胞白血病病毒 1 型（HTLV-1）是一种 C 型逆转录病毒，主要流行于日本、中美洲和南美洲、中东、非洲部分地区以及加勒比海地区。目前，全球估计有 1000 万至 2000 万人感染这种病毒。尽管大多数受感染的个体无症状，但 HTLV-1 是多种疾病的病原体，尤其是成人 T 细胞白血病/淋巴瘤（ATLL）和进行性脱髓鞘性神经疾病，即 HTLV-1 相关性脊髓病/热带痉挛性截瘫（HAM/TSP）。除了 ATLL 和 HAM/TSP，HTLV-1 还与一系列皮肤疾病有关，如与 HTLV-1 相关的感染性皮炎、结痂性疥疮和麻风病。人们对病毒与宿主反应之间相互作用的理解已经有了显著的提高，但治疗选择仍然很少。
