基于 KTTKS 胶原蛋白序列的聚二乙炔的可逆热转变。

Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence.

机构信息

School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AD, UK.

出版信息

Chem Commun (Camb). 2012 Oct 9;48(78):9774-6. doi: 10.1039/c2cc34665f.

Abstract

Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature.

摘要

在这里，我们探讨了一种通过将胶原蛋白刺激肽 KTTKS 与 10,12-二十五碳二炔酸化学偶联得到的肽两亲物的物理化学性质，该化合物可光聚合形成稳定且延伸的聚二乙炔。我们研究了这种新型聚合物的自组装，并根据热构象转变对其特殊行为进行了合理化。令人惊讶的是，该聚合物显示出与高温下β-折叠含量非协同增加相关的热转变。