Institute for Molecules and Materials, Radboud University Nijmegen, Heijendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.
Biomacromolecules. 2010 Jun 14;11(6):1676-83. doi: 10.1021/bm100376q.
Three diacetylene-containing peptide amphiphiles, with exactly the same structure, except for the position of the diacetylene moiety within the hydrophobic tail, were investigated on their assembly behavior, polymerization characteristics, and chromatic properties. After polymerization it was found that the color and, thus, the conjugation length of the polydiacetylenes was dependent both on mobility and on packing of the groups on both sides of the triple bonds. The polydiacetylene with the highest conjugation length and most stable structure was obtained when the diacetylenes were positioned in the middle of the hydrophobic tail. When the diacetylenes were close to the peptide, the mismatch between hydrogen bond and alkyl tail spacing resulted in a decreased conjugation length of the resulting polymer, while when positioned close to the end of the amphiphile the mobility of the terminal alkyl chains hampered the packing of the diacetylenes.
三种含二炔的肽两亲分子，除了疏水尾部中二炔部分的位置不同外，其余结构完全相同，研究了它们的组装行为、聚合特性和颜色性质。聚合后发现，聚二炔的颜色，因此，三键两侧基团的共轭长度既取决于其迁移率又取决于其堆积情况。当二炔位于疏水尾部中间时，可得到具有最长共轭长度和最稳定结构的聚二炔。当二炔靠近肽时，氢键和烷基尾间距不匹配会导致聚合物的共轭长度减小，而当位于两亲分子的末端时，末端烷基链的迁移性会阻碍二炔的堆积。
