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一种含BODIPY染料的苯基硼酸(PBA)的直接合成:用于连接抗体聚糖结构域的新型功能性模块化荧光工具。

A straightforward synthesis of phenyl boronic acid (PBA) containing BODIPY dyes: new functional and modular fluorescent tools for the tethering of the glycan domain of antibodies.

作者信息

Giacomazzo Gina Elena, Palladino Pasquale, Gellini Cristina, Salerno Gianluca, Baldoneschi Veronica, Feis Alessandro, Scarano Simona, Minunni Maria, Richichi Barbara

机构信息

Department of Chemistry 'Ugo Schiff', University of Florence Via Della Lastruccia 13, Sesto Fiorentino 50019 FI Italy

出版信息

RSC Adv. 2019 Sep 30;9(53):30773-30777. doi: 10.1039/c9ra07608e. eCollection 2019 Sep 26.

DOI:10.1039/c9ra07608e
PMID:35529362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9072199/
Abstract

We report here on the efficient and straightforward synthesis of a series of modular and functional PBA-BODIPY dyes 1-4. They are an outstanding example of the efficient merge of the versatility of the 3,5-dichloro-BODIPY derivatives and the receptor-like ability of the PBA moiety. The potential bioanalytical applicability of these tools was assessed by measuring the binding to glycan chains of antibodies by a Quartz Crystal Microbalance (QCM).

摘要

我们在此报告一系列模块化且功能性的PBA-硼二吡咯染料1-4的高效简便合成方法。它们是3,5-二氯-硼二吡咯衍生物的多功能性与PBA部分的受体样能力有效融合的杰出范例。通过石英晶体微天平(QCM)测量这些工具与抗体聚糖链的结合,评估了它们在生物分析方面的潜在适用性。

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