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FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy.FoxM1 敲低使人类癌细胞对蛋白酶体抑制剂诱导的细胞凋亡敏感,但对自噬不敏感。
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Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.Separase抑制剂Sepin-1抑制Foxm1表达和乳腺癌细胞生长。
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Inactivation of FoxM1 transcription factor contributes to curcumin-induced inhibition of survival, angiogenesis, and chemosensitivity in acute myeloid leukemia cells.FoxM1转录因子的失活有助于姜黄素诱导的对急性髓系白血病细胞存活、血管生成和化疗敏感性的抑制。
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FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis.FOXM1及其在胰腺癌发病机制中的致癌信号传导。
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Thiazole Antibiotics Siomycin a and Thiostrepton Inhibit the Transcriptional Activity of FOXM1.噻唑类抗生素西奥霉素A和硫链丝菌素抑制FOXM1的转录活性。
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本文引用的文献

1
Suppression of FOXM1 sensitizes human cancer cells to cell death induced by DNA-damage.抑制 FOXM1 可使人类癌细胞对 DNA 损伤诱导的细胞死亡敏感。
PLoS One. 2012;7(2):e31761. doi: 10.1371/journal.pone.0031761. Epub 2012 Feb 29.
2
The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA.小干扰RNA对乳腺癌异种移植瘤中FOXM1及其靶标的抑制作用。
Oncotarget. 2011 Dec;2(12):1218-26. doi: 10.18632/oncotarget.359.
3
Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells.核仁磷酸蛋白与 FOXM1 相互作用,并调节人癌细胞中 FOXM1 的水平和定位。
J Biol Chem. 2011 Dec 2;286(48):41425-41433. doi: 10.1074/jbc.M111.270843. Epub 2011 Oct 6.
4
Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts.胶束包裹噻唑霉素作为一种有效的纳米药物,可抑制肿瘤生长,并在人异种移植瘤中抑制 FOXM1。
Mol Cancer Ther. 2011 Dec;10(12):2287-97. doi: 10.1158/1535-7163.MCT-11-0536. Epub 2011 Sep 8.
5
A new target for proteasome inhibitors: FoxM1.一种新的蛋白酶体抑制剂靶标:FoxM1。
Expert Opin Investig Drugs. 2010 Feb;19(2):235-42. doi: 10.1517/13543780903563364.
6
p53 negatively regulates expression of FoxM1.p53负向调节FoxM1的表达。
Cell Cycle. 2009 Oct 15;8(20):3425-7. doi: 10.4161/cc.8.20.9628. Epub 2009 Oct 25.
7
FoxM1 is a general target for proteasome inhibitors.FoxM1 是蛋白酶体抑制剂的一个通用靶标。
PLoS One. 2009 Aug 12;4(8):e6593. doi: 10.1371/journal.pone.0006593.
8
Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells.噻唑类抗生素靶向FoxM1并诱导人癌细胞凋亡。
PLoS One. 2009;4(5):e5592. doi: 10.1371/journal.pone.0005592. Epub 2009 May 18.
9
A novel mode of FoxM1 regulation: positive auto-regulatory loop.FoxM1调控的一种新模式:正向自调节环路。
Cell Cycle. 2009 Jun 15;8(12):1966-7. doi: 10.4161/cc.8.12.8708. Epub 2009 Jun 9.
10
FOXM1: the Achilles' heel of cancer?FOXM1:癌症的阿喀琉斯之踵?
Nat Rev Cancer. 2008 Mar;8(3):c1; author reply c2. doi: 10.1038/nrc2223-c1.

致癌转录因子 FOXM1 与抗癌治疗。

The oncogenic transcription factor FOXM1 and anticancer therapy.

出版信息

Cell Cycle. 2012 Sep 15;11(18):3341-2. doi: 10.4161/cc.21841. Epub 2012 Aug 23.

DOI:10.4161/cc.21841
PMID:22918255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3466533/
Abstract

Comment on: Halasi M,et al. PLoS ONE 2012; 7:e31761.

摘要

评 Halasi M 等人的 PLoS ONE 2012 论文:31761 号。