Department of Pathology, Karmanos Cancer Institute, Wayne State University, 540 E. Canfield, Detroit, MI 48201, USA.
Cancer Treat Rev. 2010 Apr;36(2):151-6. doi: 10.1016/j.ctrv.2009.11.006. Epub 2009 Dec 22.
FoxM1 signaling has been reported to be associated with carcinogenesis. Therefore, the FoxM1 may represent a novel therapeutic target, and thus the development of agents that will target FoxM1 is likely to have significant therapeutic impact on human cancer. This review describes the mechanisms of signal transduction associated with FoxM1 and provides emerging evidence in support of its role in the carcinogenesis. Further, we summarize data on several FoxM1 inhibitors especially "chemopreventive agents" and these agents could be useful for targeted inactivation of FoxM1, which indeed could become a novel approach for the prevention and/or treatment of human cancer.
FoxM1 信号已被报道与致癌作用有关。因此，FoxM1 可能代表了一个新的治疗靶点，因此开发针对 FoxM1 的药物可能会对人类癌症的治疗产生重大影响。本综述描述了与 FoxM1 相关的信号转导机制，并提供了支持其在致癌作用中的作用的新证据。此外，我们总结了几种 FoxM1 抑制剂的数据，特别是“化学预防剂”，这些抑制剂可能对靶向灭活 FoxM1 有用，这确实可能成为预防和/或治疗人类癌症的新方法。
