Karaaltin M V, Ozalp B, Dadaci M, Kayikcioglu A, Kecik A, Oner F
Department of Plastic, Reconstructive, and Aesthetic Surgery, Bezmi Alem Vakif University, Fatih-Istanbul, Turkey.
J Hand Surg Eur Vol. 2013 Jul;38(6):651-7. doi: 10.1177/1753193412458646. Epub 2012 Aug 23.
This study investigated the effects of 5-fluorouracil in a slow-release biodegradable gelatin system on tendon healing. Gelatin blocks prepared in a size of 10 × 20 × 1 mm were loaded with 10, 20, and 30 mg of 5-fluorouracil, and 30 adult white Leghorn chickens were used. The tendons to the third and fourth toes were severed and repaired. The extremities were casted for three weeks. After sacrifice, the tendons were examined histologically and biomechanically for adhesion formation. The 10 mg-loaded gelatin group showed a decrease in adhesion formation when compared with the operative control group; the 20 and 30 mg groups showed signs of severe inflammation. Low doses of 5-fluorouracil applied via a slow-release gelatin system reduced adhesion formation in flexor tendon healing.
本研究调查了5-氟尿嘧啶在缓释可生物降解明胶系统中对肌腱愈合的影响。制备尺寸为10×20×1毫米的明胶块，分别加载10毫克、20毫克和30毫克的5-氟尿嘧啶，并使用30只成年白色来亨鸡。切断并修复第三和第四趾的肌腱。肢体固定三周。处死后，对肌腱进行组织学和生物力学检查以评估粘连形成情况。与手术对照组相比，加载10毫克的明胶组粘连形成减少；20毫克和30毫克组出现严重炎症迹象。通过缓释明胶系统应用低剂量的5-氟尿嘧啶可减少屈肌腱愈合中的粘连形成。
