Capella-Monsonís Héctor, Kearns Stephen, Kelly Jack, Zeugolis Dimitrios I
Regenerative, Modular and Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
BMC Biomed Eng. 2019 Feb 27;1:5. doi: 10.1186/s42490-019-0005-0. eCollection 2019.
Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or mesothelial layer of tissue, which leads to fibrin adhesion sites due to the downregulation of fibrinolytic activity and an increase in fibrin deposition. Hence, the metabolic events involved in tissue healing, coagulation, inflammation, fibrinolysis and angiogenesis play a pivotal role in adhesion formation. Understanding these events, their interactions and their influence on the development of post-surgical adhesion is crucial for the development of effective therapies to prevent them. Mechanical barriers, antiadhesive agents and combination thereof are customarily used in the battle against adhesions. Although these systems seem to be effective at reducing adhesions in clinical procedures, their prevention remains still elusive, imposing the need for new antiadhesive strategies.
粘连是临床实践中的一个主要负担，尤其是在腹部、子宫内、心包和肌腱手术后。粘连始于组织上皮或间皮层的破坏，由于纤溶活性下调和纤维蛋白沉积增加，导致纤维蛋白粘连部位形成。因此，组织愈合、凝血、炎症、纤维蛋白溶解和血管生成中涉及的代谢事件在粘连形成中起关键作用。了解这些事件、它们之间的相互作用以及它们对术后粘连发展的影响，对于开发有效的预防疗法至关重要。机械屏障、抗粘连剂及其组合通常用于对抗粘连。尽管这些系统在临床手术中似乎能有效减少粘连，但粘连的预防仍然难以实现，这就需要新的抗粘连策略。
