Ipsen J H, Jørgensen K, Mouritsen O G
Department of Structural Properties of Materials, Technical University of Denmark, Lyngby.
Biophys J. 1990 Nov;58(5):1099-107. doi: 10.1016/S0006-3495(90)82452-8.
A systematic computer simulation study is conducted for a model of the main phase transition of fully hydrated saturated diacyl phosphatidylcholine bilayers (DMPC, DPPC, and DSPC). With particular focus on the fluctuation effects on the thermal properties in the transition region, the study yields data for the specific heat, the lateral compressibility, and the lipid-domain size distribution. Via a simple model assumption the transmembrane passive ion permeability is derived from the lipid-domain interfacial measure. A comparative analysis of the various data shows, in agreement with a number of experiments, that the lateral density fluctuations and hence the response functions increase as the acyl-chain length is decreased.
对完全水合的饱和二酰基磷脂酰胆碱双层膜（二肉豆蔻酰磷脂酰胆碱、二棕榈酰磷脂酰胆碱和二硬脂酰磷脂酰胆碱）的主要相变模型进行了系统的计算机模拟研究。该研究特别关注过渡区域中热性质的涨落效应，得出了比热、横向压缩性和脂质域尺寸分布的数据。通过一个简单的模型假设，从脂质域界面测量中推导出跨膜被动离子渗透率。各种数据的对比分析表明，与许多实验结果一致，随着酰基链长度的减小，横向密度涨落以及响应函数会增加。
