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2型糖尿病患者的心血管危险因素与踝臂指数分布

Cardiovascular Risk Factors and Distributions of the Ankle-Brachial Index among Type 2 Diabetes Mellitus Patients.

作者信息

Doza Badaruddoza, Kaur Manpreet, Chopra Sonia, Kapoor Rohit

机构信息

Department of Human Genetics, Guru Nanak Dev University, Punjab, Amritsar 143005, India.

出版信息

Int J Hypertens. 2012;2012:485812. doi: 10.1155/2012/485812. Epub 2012 Aug 5.

Abstract

Background. The aim of present study is to observe the association between the levels of ankle-brachial index (ABI) and cardiovascular risk factors among people with type 2 diabetes mellitus in north India. A cross-sectional study was carried out at a centre for heart and diabetic clinic in the state of Punjab on 1121 subjects (671 males and 450 females) with type 2 diabetes mellitus. History of symptoms related to cardiovascular diseases was noted, and blood pressure and anthropometric measurements were recorded. Ankle-brachial index (ABI) was measured using ultrasonic Doppler flow detector. Subjects with ABI ≤0.9 and ≥1.30 were classified as having low and high ABI, respectively. Females had a higher BMI and brachial-ankle pulse wave velocity (P < 0.001). Whereas, males had higher diastolic blood pressure and duration of type 2 diabetes mellitus. The differences of systolic blood pressure and ankle-brachial index were not found significant between the sexes. The prevalence of low ABI (<0.9) was 4.47% in men and 4.67% in women and high ABI (≥1.30) was prevalent in 14% of men and 10.45% of women. Age, BMI, baPWV, and blood pressures were significantly associated with ABI value in both sexes. The results suggested that the ABI might be used as a strong indicator for cardiovascular risk factors in type 2 diabetic subjects.

摘要

背景。本研究的目的是观察印度北部2型糖尿病患者的踝臂指数(ABI)水平与心血管危险因素之间的关联。在旁遮普邦一家心脏与糖尿病诊所对1121名2型糖尿病患者(671名男性和450名女性)进行了一项横断面研究。记录了心血管疾病相关症状史,并测量了血压和人体测量数据。使用超声多普勒血流探测器测量踝臂指数(ABI)。ABI≤0.9和≥1.30的受试者分别被分类为ABI低和高。女性的体重指数(BMI)和臂踝脉搏波速度较高(P<0.001)。而男性的舒张压和2型糖尿病病程较长。收缩压和踝臂指数在性别之间的差异未发现有统计学意义。男性低ABI(<0.9)的患病率为4.47%,女性为4.67%;高ABI(≥1.30)在男性中的患病率为14%,在女性中的患病率为10.45%。年龄、BMI、臂踝脉搏波速度(baPWV)和血压在两性中均与ABI值显著相关。结果表明,ABI可能用作2型糖尿病患者心血管危险因素的一个重要指标。

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