Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120 China.
Int J Med Sci. 2013;10(2):183-90. doi: 10.7150/ijms.5308. Epub 2013 Jan 9.
High ankle-brachial index (ABI) is marker of increased cardiovascular morbidity and mortality, while the relationship and mechanism between high ABI and metabolic syndrome (MetS) are unclear. The objectives of this study were to determine the relationship and possible mechanism of MetS with high ABI.
341 participants without CRF were recruited. Among these participants, 58 participants (ABI ≥ 1.3) were include in high ABI group and the other 283 participants (0.9 < ABI < 1.3) were include in normal ABI group. Furthermore, these 341 participants were also divided into MetS group (n = 54) and non-MetS group (n = 287). All participants received examinations including body mass index (BMI), ABI and related biochemical parameters.
Compared with non-MetS group, the prevalence of high ABI was higher in MetS group (27.8% vs. 15%, p < 0.05). Participants with 3-4 metabolic risk factors had higher prevalence of high ABI than those with 0-1 metabolic risk factors (27.8% vs. 12.7%, p < 0.05). The prevalence of high ABI in overweight participants was higher than those with normal body weight. And the participants with hypertension also had higher prevalence of high ABI than normotensive participants. BMI, high-sensitivity C-reactive protein (hsCRP) and superoxide dismutase (SOD) were all higher in high ABI group than normal ABI group (p < 0.05).
More metabolic risk factors have increased the risk of high ABI. Inflammation and oxidative stress are associated with prevalence of high ABI in metabolic syndrome patients without chronic renal failure.
高踝臂指数(ABI)是心血管发病率和死亡率增加的标志物,而高 ABI 与代谢综合征(MetS)之间的关系和机制尚不清楚。本研究的目的是确定 MetS 与高 ABI 之间的关系和可能的机制。
共招募了 341 名无慢性肾衰竭(CRF)的参与者。其中,58 名参与者(ABI≥1.3)被纳入高 ABI 组,其余 283 名参与者(0.9<ABI<1.3)被纳入正常 ABI 组。此外,这 341 名参与者还分为 MetS 组(n=54)和非 MetS 组(n=287)。所有参与者均接受了包括体重指数(BMI)、ABI 和相关生化参数在内的检查。
与非 MetS 组相比,MetS 组的高 ABI 患病率更高(27.8%比 15%,p<0.05)。有 3-4 个代谢危险因素的参与者比有 0-1 个代谢危险因素的参与者有更高的高 ABI 患病率(27.8%比 12.7%,p<0.05)。超重参与者的高 ABI 患病率高于体重正常者。高血压参与者的高 ABI 患病率也高于血压正常者。高 ABI 组的 BMI、高敏 C 反应蛋白(hsCRP)和超氧化物歧化酶(SOD)均高于正常 ABI 组(p<0.05)。
更多的代谢危险因素增加了高 ABI 的风险。在无慢性肾衰竭的代谢综合征患者中,炎症和氧化应激与高 ABI 的患病率有关。