Sen Aditi, Kanani Shubhada
Department of Foods and Nutrition, The Maharaja Sayajirao University of Baroda, 14 Anupam Society, Behind Pizza Inn, Jetalpur Road, Vadodara 390007, India.
ISRN Hematol. 2012;2012:482153. doi: 10.5402/2012/482153. Epub 2012 Jul 26.
In view of high iron needs for adolescent growth, this paper studied the impact of daily vs. intermittent (once and twice weekly) iron folic acid (IFA) supplementation on hemoglobin levels and pubertal growth among primary school girls in early adolescence (9-13 years) of Vadodara, India. Methods. Hemoglobin (Hb), height and weight of the girls were assessed using standard methods. In three experimental schools (ES) IFA tablets in a dose of 100 mg Fe + 0.5 mg folic acid was given either daily, once weekly or twice weekly for one year. The fourth school (control: CS) did not receive any intervention. Results. Hb levels significantly improved (P < 0.01) in all ES compared to CS. Body Mass Index (BMI) increment in ES vs CS was significant (P < 0.05) in twice weekly IFA and daily IFA. Within ES groups, mean Hb and BMI increments were comparable between twice weekly IFA and daily IFA. Anemic ES girls showed higher Hb and BMI increments vs. non-anemic girls. Better the Hb response, greater was the benefit on BMI.
Twice-weekly IFA supplementation was comparable to daily IFA as regards impact on Hb and growth; at less cost and greater feasibility. Once-weekly dose was inadequate to significantly improve growth.
鉴于青少年生长对铁的需求量较高，本文研究了每日补充与间歇补充（每周一次和每周两次）铁叶酸（IFA）对印度瓦多达拉市青春期早期（9 - 13岁）小学女生血红蛋白水平和青春期生长的影响。方法：采用标准方法评估女生的血红蛋白（Hb）、身高和体重。在三所实验学校（ES）中，给予剂量为100毫克铁 + 0.5毫克叶酸的IFA片剂，分别为每日、每周一次或每周两次，持续一年。第四所学校（对照：CS）未接受任何干预。结果：与CS相比，所有ES组的Hb水平均显著改善（P < 0.01）。每周两次IFA组和每日IFA组的ES与CS相比，体重指数（BMI）增加显著（P < 0.05）。在ES组内，每周两次IFA组和每日IFA组的平均Hb和BMI增加量相当。贫血的ES女生与非贫血女生相比，Hb和BMI增加量更高。Hb反应越好，对BMI的益处越大。
每周两次补充IFA在对Hb和生长的影响方面与每日补充IFA相当；成本更低且可行性更高。每周一次的剂量不足以显著促进生长。
