Lawless J W, Latham M C, Stephenson L S, Kinoti S N, Pertet A M
Program in International Nutrition, Cornell University, Ithaca, NY 14853-6301.
J Nutr. 1994 May;124(5):645-54. doi: 10.1093/jn/124.5.645.
A randomized, double-blind, placebo-controlled iron supplementation trial was conducted in Kenya to examine the effect of iron supplements on appetite and growth in 87 primary school children. Sustained-release ferrous sulfate (150 mg) or placebo tablets were provided daily at school for 14 wk. Prior to tablet administration, baseline anthropometry, iron nutritional status (hemoglobin and serum ferritin), parasitic infections and clinical indicators of morbidity were measured. A baseline appetite test was conducted twice on each child by quantitatively measuring the ad libitum consumption of a midmorning snack. In addition, each child was asked for a subjective assessment of his or her appetite. Follow-up exams and appetite tests were identical to those at baseline. Findings indicated that provision of iron supplements resulted in improved growth and improved appetite (in terms of both energy intake of the snack and child report of appetite) as compared with children receiving the placebo. The increased energy intake from the snack was 10% of the daily estimated energy intake for children of this same age group living elsewhere in Kenya. Further research into the underlying physiological mechanisms may shed light on the relationship between iron nutritional status and appetite.
在肯尼亚进行了一项随机、双盲、安慰剂对照的铁补充剂试验，以研究铁补充剂对87名小学生食欲和生长的影响。在学校每天提供缓释硫酸亚铁（150毫克）或安慰剂片，持续14周。在服用片剂之前，测量了基线人体测量学、铁营养状况（血红蛋白和血清铁蛋白）、寄生虫感染和发病的临床指标。通过定量测量上午课间点心的随意摄入量，对每个孩子进行了两次基线食欲测试。此外，还要求每个孩子对自己的食欲进行主观评估。随访检查和食欲测试与基线时相同。研究结果表明，与接受安慰剂的儿童相比，提供铁补充剂可促进生长并改善食欲（就点心的能量摄入量和儿童的食欲报告而言）。从点心增加的能量摄入量是肯尼亚其他地方同年龄组儿童每日估计能量摄入量的10%。对潜在生理机制的进一步研究可能会揭示铁营养状况与食欲之间的关系。
