Kim M S, Jo Y H, Yoon S H, Hahn S J, Rhie D J, Kim C C, Choi H
Department of Physiology, Catholic University Medical College, Seoul, Korea.
Brain Res. 1990 Aug 6;524(2):208-12. doi: 10.1016/0006-8993(90)90692-5.
One hundred and twenty-seven conscious rats prepared with chronic gastric fistula were studied to investigate the effect of stimulation of the medial amygdala on gastric acid secretion. Gastric acid output was significantly increased by electrical stimulation of the medial amygdala in normal rats and the increase in acid secretion was completely abolished by vagotomy. Vagotomized rats, with or without amygdaloid stimulation, showed comparable levels of gastric acid output which were significantly lower than in controls. These results indicate that the amygdala effect on gastric acid secretion is carried via the vagus nerve. Subcutaneous injections of high doses of histamine increased gastric acid secretion which was further increased by amygdaloid stimulation. Plasma levels of gastrin were not significantly changed by stimulation of the medial amygdala with or without vagotomy. From the above results, we concluded that in conscious rats the medial amygdala plays a significant role in stimulating gastric acid secretion, the vagus nerve is involved in this process, but it is not mediated by release of either histamine or gastrin.
对127只制备了慢性胃瘘的清醒大鼠进行研究，以探讨刺激内侧杏仁核对胃酸分泌的影响。在正常大鼠中，电刺激内侧杏仁核可使胃酸分泌显著增加，而迷走神经切断术可完全消除胃酸分泌的增加。无论是否进行杏仁核刺激，迷走神经切断的大鼠胃酸分泌水平相当，且显著低于对照组。这些结果表明，杏仁核对胃酸分泌的影响是通过迷走神经传导的。皮下注射高剂量组胺可增加胃酸分泌，杏仁核刺激可使其进一步增加。无论是否进行迷走神经切断术，刺激内侧杏仁核均未显著改变胃泌素的血浆水平。根据上述结果，我们得出结论，在清醒大鼠中，内侧杏仁核在刺激胃酸分泌中起重要作用，迷走神经参与这一过程，但这一过程不是由组胺或胃泌素的释放介导的。
