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[胎儿心率变异性与氯氮平治疗]

[Fetal heart rate variability and clozapine treatment].

作者信息

Coston A-L, Hoffmann P, Equy V, Sergent F, Vidal C

机构信息

Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Couple Enfant, université Joseph-Fourrier Grenoble 1, CHU de Grenoble, BP 217, 38043 Grenoble cedex 9, France.

出版信息

Gynecol Obstet Fertil. 2012 Sep;40(9):549-52. doi: 10.1016/j.gyobfe.2012.07.004. Epub 2012 Aug 21.

DOI:10.1016/j.gyobfe.2012.07.004
PMID:22920232
Abstract

We report the 2 cases of schizophrenic patients with clozapine treatment and particularly, we underlined a reduced variability and low short-term variability, whereas biophysical ultrasound score, Dopplers and perception of fetal movements were acceptable and comfortable concerning the fetal vitality. Our aim is to show the limits of the analyzed fetal heart rate under clozapine. So, we may change our observation of fetus in chronic suffering that is usually mainly made with an informatics analysis of pregnants under clozapine.

摘要

我们报告了2例接受氯氮平治疗的精神分裂症患者的情况,特别强调了其变异性降低和短期变异性低,而生物物理超声评分、多普勒检查和胎动感知在胎儿活力方面是可接受且令人满意的。我们的目的是展示氯氮平治疗下分析胎儿心率的局限性。因此,对于长期患病孕妇,我们可能会改变通常主要基于对服用氯氮平孕妇进行信息学分析的胎儿观察方式。

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[Fetal heart rate variability and clozapine treatment].[胎儿心率变异性与氯氮平治疗]
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引用本文的文献

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Clozapine treatment of a Japanese patient during pregnancy: Effect on fetal heart rate.氯氮平治疗一名日本孕妇:对胎儿心率的影响。
Neuropsychopharmacol Rep. 2024 Dec;44(4):852-856. doi: 10.1002/npr2.12486. Epub 2024 Sep 16.
2
Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety-Particularities in the Context of COVID-19.氯氮平:COVID-19背景下药物遗传生物标志物、风险及安全性特点的最新综述
Brain Sci. 2020 Nov 11;10(11):840. doi: 10.3390/brainsci10110840.
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Clozapine Use During Pregnancy and Lactation: A Case-Series Report.
孕期及哺乳期使用氯氮平:病例系列报告
Front Pharmacol. 2018 Mar 27;9:264. doi: 10.3389/fphar.2018.00264. eCollection 2018.
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Mood stabilizers in pregnancy and lactation.孕期及哺乳期的心境稳定剂
Indian J Psychiatry. 2015 Jul;57(Suppl 2):S308-23. doi: 10.4103/0019-5545.161498.