Department of Dentomaxillofacial Radiology, Affiliated Stomatology Hospital of Medical School, Nanjing University, Zhong Yang Road 30, Nanjing, China.
J Craniomaxillofac Surg. 2013 Apr;41(3):190-3. doi: 10.1016/j.jcms.2012.07.012. Epub 2012 Aug 21.
Ameloblastoma is characterized by slow-growing, local invasiveness and high incidence of local recurrence. It usually presents with a benign histological appearance. However, ameloblastoma occasionally demonstrates a clinical course that is characteristic of malignant transformation. Here, we present a case of ameloblastoma with an aggressive clinical course, including multiple recurrences, a short disease-free interval, pulmonary metastasis and extensive skull-base infiltration. With a careful re-evaluation of the histology and cytology of the specimens of primary and recurrent ameloblastoma in 2006 and 2007, malignant transformation was observed and carcinoma ex ameloblastoma was ultimately diagnosed.
造釉细胞瘤以生长缓慢、局部侵袭性和高局部复发率为特征。它通常表现出良性组织学外观。然而，造釉细胞瘤偶尔会表现出具有恶性转化特征的临床过程。在这里，我们报告了一例具有侵袭性临床过程的造釉细胞瘤病例，包括多次复发、无病间隔短、肺转移和广泛的颅底浸润。通过仔细重新评估 2006 年和 2007 年原发性和复发性造釉细胞瘤标本的组织学和细胞学，观察到恶性转化，并最终诊断为造釉细胞瘤恶变。
