无金属的供体/受体卡宾的 N-H 插入反应。
Metal-free N-H insertions of donor/acceptor carbenes.
机构信息
Emory University, Department of Chemistry, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
出版信息
Org Lett. 2012 Sep 7;14(17):4626-9. doi: 10.1021/ol3020754. Epub 2012 Aug 24.
PMID:22920795
Abstract
Synthetically useful transformations arise from the thermal decomposition of aryldiazoacetates in the presence of primary and secondary amines without the use of a metal catalyst. Thermally generated, free donor/acceptor carbenes directly undergo N-H insertion with amines through selective aza-ylide formation to afford a variety of α-amino esters in 53-96% yields.
摘要
在没有金属催化剂的情况下，芳基重氮乙酸酯的热分解可以产生具有合成用途的转化，而无需使用金属催化剂。热生成的自由供体/受体卡宾可以通过选择性氮杂叶立德的形成直接与胺进行 N-H 插入，从而以 53-96%的收率得到各种α-氨基酯。
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