可见光诱导的无金属卡宾-咔唑化反应

Empel Claire, Patureau Frederic W, Koenigs Rene M

Institute of Organic Chemistry , RWTH Aachen University , Landoltweg 1 , 52074 Aachen , Germany.

J Org Chem. 2019 Sep 6;84(17):11316-11322. doi: 10.1021/acs.joc.9b01753. Epub 2019 Aug 15.

Metal-free N-H functionalization reactions represent an important strategy for sustainable C-N coupling reactions. In this report, we describe the visible light photolysis of aryl diazoacetates in the presence of some heterocycles that enables mild, metal-free N-H functionalization reactions of carbazole and azepine heterocycles (15 examples, up to 83% yield).

无金属的N-H官能化反应是可持续C-N偶联反应的重要策略。在本报告中，我们描述了在一些杂环存在下芳基重氮乙酸酯的可见光光解反应，该反应能够实现咔唑和氮杂环庚烷杂环的温和、无金属N-H官能化反应（15个例子，产率高达83%）。