Cateau Estelle, Rodier Marie-Hélène, Imbert Christine
Laboratoire de parasitologie-mycologie médicale, université de Poitiers, UMR CNRS 6008, bâtiment urgence et biologie médicale (UBM), 2, rue de la Milétrie, 86021 Poitiers Cedex, France.
Med Sci (Paris). 2012 Aug-Sep;28(8-9):740-5. doi: 10.1051/medsci/2012288016. Epub 2012 Aug 22.
Fungal biofilms associated with inserted medical devices such as catheters, represent a major risk factor for candidemia. In addition, these biofilm yeasts show a decreased susceptibility to antifungal agents. Recently, a new therapeutic approach has emerged, the "lock therapy", based on the use of high concentrations of antimicrobials, instilled into the lumen of the catheter and left in place for 8 to 12 h. In vitro or in vivo studies have evaluated the interest of antifungal locks using amphotericin B, an azole or echinocandins. The promising results will permit us to discuss the relevance of this technique.
与诸如导管等插入式医疗设备相关的真菌生物膜是念珠菌血症的主要危险因素。此外，这些生物膜酵母对抗真菌剂的敏感性降低。最近，出现了一种新的治疗方法——“锁疗法”，即基于使用高浓度抗菌剂，将其注入导管内腔并留置8至12小时。体外或体内研究评估了使用两性霉素B、唑类或棘白菌素进行抗真菌封管的效果。这些有前景的结果将使我们能够讨论该技术的相关性。
