Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine Department of Pediatrics Department of Microbiology and Immunology, Weill Cornell Medical Center of Cornell University, New York, New York.
Astellas Pharma Global Development, Northbrook, Illinois.
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S601-3. doi: 10.1093/cid/civ676.
Echinocandins are N-acyl-substituted cyclic hexapeptides with potent in vitro and in vivo activity against Candida species that are used for primary treatment and prevention of candidemia and invasive candidiasis. Recent progress in the translational research of echinocandins has led to new approaches for treatment of central venous catheter Candida biofilms. Other studies have laid the experimental and clinical foundation for use of extended dosing intervals for administration of echinocandins in treatment and prevention of candidemia and invasive candidiasis.
棘白菌素类是 N-酰基取代的环六肽，具有很强的抗念珠菌属的体外和体内活性，用于念珠菌血症和侵袭性念珠菌病的初始治疗和预防。棘白菌素类的转化研究的最新进展为治疗中心静脉导管念珠菌生物膜提供了新的方法。其他研究为延长棘白菌素类给药间隔时间用于治疗和预防念珠菌血症和侵袭性念珠菌病奠定了实验和临床基础。
