Chen J Z
Gansu Provincial Tumor Hospital, Lanzhou.
Zhong Xi Yi Jie He Za Zhi. 1990 Dec;10(12):717-9, 707.
This study observed the effect of chemotherapy combined with Chinese herbs and western drugs on white blood cell count in 31 patients with gastric cancer. These patients were divided into 3 groups: (1) Fu Zheng (strengthen the body resistance) with invigorating the Spleen and Kidney recipe; (2) Fu Zheng with western drugs raising WBC and enhancing immunity; (3) Gong Xiao (eliminating the evil factors and mass) with promoting blood circulation to remove blood stasis recipe or eliminating the evil factors and mass recipe. After chemotherapy, the mean of WBC count was greater than 4.0 X 10(9)/L in group I; less than 3.5 X 10(9)/L in group II; less than 3.0 X 10(9)/L in group III. Because of WBC count below 3.0 X 10(9)/L, in group II there were 5 cases (5/14) whose chemotherapies had to be discontinued, and in group III there were 4 cases (4/6). While all patients were completed their chemotherapies in group I. Its statistical difference was significant (P less than 0.05). It suggested that invigorating the Spleen and Kidney recipe had specific effect on decreasing the toxicity and side effect of chemotherapy, preventing bone marrow suppression and leukopenia, and was better than western drugs used in group II. It showed in the treatment of cancer with TCM, we must pay attention to the relationship between the Fu Zheng and the Gong Xiao.
本研究观察了化疗联合中药及西药对31例胃癌患者白细胞计数的影响。这些患者被分为3组：（1）采用健脾补肾方剂扶正；（2）采用升高白细胞及增强免疫力的西药扶正；（3）采用活血化瘀方剂或祛邪散结方剂攻消。化疗后，I组白细胞计数平均值大于4.0×10⁹/L；II组小于3.5×10⁹/L；III组小于3.0×10⁹/L。由于II组白细胞计数低于3.0×10⁹/L，有5例（5/14）患者不得不中断化疗，III组有4例（4/6）。而I组所有患者均完成了化疗。其统计学差异有显著性（P<0.05）。提示健脾补肾方剂对降低化疗的毒副作用、预防骨髓抑制和白细胞减少有特效，且优于II组所用的西药。表明在中医治疗癌症时，必须重视扶正与攻消的关系。
