Wang G M, Chen C H, Sun G Z
Guang-an-men Hospital, China Academy of TCM, Beijing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Nov;14(11):661-3.
61 cases of the gastric cancers have been treated with Replenishing Qi and Invigorating Spleen (RQIS) combined with chemotherapy. The patients were divided into treated group and control group randomly, The results showed that: rate of the adverse effects, e.g. nausea, vomiting, anorexia, diarrhea etc. were higher in the chemotherapy used patients, combined treated groups were lower significantly (P < 0.01-0.001). Rate of chemotherapy completion was 95% in the treated group, 78% in control group, the difference was significant (P < 0.01). WBC and blood platelet were reduced in the treatment group and chemotherapy group, they were 30% and 45% respectively (P < 0.01). Superoxide dismutase was increased obviously (P < 0.01). It revealed that RQIS could scavenge the free radical potently. 60 cases of gastric cancers have been treated over 1 year, the survival rates of 1 year, 3 years, 5 years were 98.36%, 82.69%, 60.00% respectively after following up. Among them, survival rate of III stage patients was 57.14%. Animal experimental study showed that the inhibition rates of lung metastasis were 92.2% and 83.7% in mice B16 of RQIS groups. The difference was significant than that of control group. They could elevate the tolerance to chemotherapy in mice.
61例胃癌患者采用益气健脾法结合化疗进行治疗。将患者随机分为治疗组和对照组，结果显示：单纯化疗患者恶心、呕吐、厌食、腹泻等不良反应发生率较高，联合治疗组明显较低（P<0.01 - 0.001）。治疗组化疗完成率为95%，对照组为78%，差异有统计学意义（P<0.01）。治疗组和化疗组白细胞及血小板均有下降，分别下降30%和45%（P<0.01）。超氧化物歧化酶明显升高（P<0.01）。提示益气健脾法能有效清除自由基。60例胃癌患者经1年以上治疗，随访后1年、3年、5年生存率分别为98.36%、82.69%、60.00%。其中Ⅲ期患者生存率为57.14%。动物实验研究表明，益气健脾法组小鼠B16肺癌转移抑制率分别为92.2%和83.7%。与对照组相比差异有统计学意义。它们能提高小鼠对化疗的耐受性。
