Department of Animal Breeding and Genetics, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.
Anim Reprod Sci. 2012 Sep;134(1-2):36-44. doi: 10.1016/j.anireprosci.2012.08.009. Epub 2012 Aug 11.
Advanced genomic analysis has revealed an enormous inventory of non-coding RNAs (ncRNAs), which are functionally important at transcriptional and post-transcriptional level for different cellular processes. Among the ncRNAs, microRNAs (miRNAs) have recently been highlighted extensively for their pivotal role in disease, fertility and development through post-transcriptional regulation of gene expression. The presence and spatio-temporal expression of miRNAs and miRNA processing machinery genes in oocytes and preimplantation embryos has evidenced the involvement of miRNAs for growth and maturation of mammalian oocytes, early embryonic development, stem cell lineage differentiation and implantation. Therefore, this article aims to highlight primary evidences on the importance of miRNAs and their mediated translational reprogramming in the physiology and development of mammalian oocytes and embryos.
高级基因组分析揭示了大量非编码 RNA（ncRNA），它们在转录和转录后水平上对不同的细胞过程具有重要的功能。在 ncRNA 中，microRNAs（miRNAs）最近因其在疾病、生育和发育中的关键作用而受到广泛关注，其通过对基因表达的转录后调控来发挥作用。miRNAs 和 miRNA 加工机制基因在卵母细胞和植入前胚胎中的存在和时空表达，证明了 miRNAs 参与了哺乳动物卵母细胞的生长和成熟、早期胚胎发育、干细胞谱系分化和着床。因此，本文旨在强调 miRNA 及其介导的翻译重编程在哺乳动物卵母细胞和胚胎的生理和发育中的重要性的主要证据。
