Biothermal Technology Laboratory, Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Cryobiology. 2012 Dec;65(3):270-7. doi: 10.1016/j.cryobiol.2012.08.001. Epub 2012 Aug 15.
There is an undisputed need for temperature-field reconstruction during minimally invasive cryosurgery. The current line of research focuses on developing miniature, wireless, implantable, temperature sensors to enable temperature-field reconstruction in real time. This project combines two parallel efforts: (i) to develop the hardware necessary for implantable sensors, and (ii) to develop mathematical techniques for temperature-field reconstruction in real time-the subject matter of the current study. In particular, this study proposes an approach for temperature-field reconstruction combining data obtained from medical imaging, cryoprobe-embedded sensors, and miniature, wireless, implantable sensors, the development of which is currently underway. This study discusses possible strategies for laying out implantable sensors and approaches for data integration. In particular, prostate cryosurgery is presented as a developmental model and a two-dimensional proof-of-concept is discussed. It is demonstrated that the lethal temperature can be predicted to a significant degree of certainty with implantable sensors and the technique proposed in the current study, a capability that is yet unavailable.
在微创冷冻手术中，重建温度场是毋庸置疑的需求。目前的研究重点是开发微型、无线、可植入的温度传感器，以实现实时温度场重建。本项目结合了两项并行的工作：（i）开发可植入传感器所需的硬件，（ii）开发实时温度场重建的数学技术——这是当前研究的主题。具体来说，本研究提出了一种结合医学成像、冷冻探针嵌入式传感器以及微型、无线、可植入传感器获得的数据进行温度场重建的方法，目前正在开发中。本研究讨论了可植入传感器的布局策略和数据集成方法。特别是，以前列腺冷冻手术为例，提出了一种发展模型，并讨论了二维概念验证。研究表明，通过可植入传感器和本研究提出的技术，可以在很大程度上预测致死温度，而这是目前无法实现的。
