United Graduate School of Veterinary Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Exp Parasitol. 2012 Nov;132(3):327-33. doi: 10.1016/j.exppara.2012.08.004. Epub 2012 Aug 16.
Hemolytic activity for animals infected with various Babesia species is well reported. In this study, we confirmed that serum of Babesia rodhaini-infected mice also showed hemolytic activity. Erythrocytes from non-infected mice were lysed by co-incubation with B. rodhaini-infected serum. Catalase activity of the non-infected target erythrocytes was suppressed after this co-incubation with the hemolytic serum of B. rodhaini-infected mice. Furthermore, serum hemolytic activity was inhibited when target erythrocytes were incubated with hemolytic serum in the presence of exogenous catalase. Our study indicated that hemolytic serum can down-regulate the antioxidant capacity of non-infected healthy erythrocytes, possibly as a result of catalase activity, thereby leading to hemolysis.
已感染各种巴贝西亚物种的动物的溶血活性已有相关报道。在这项研究中，我们证实感染罗德西亚巴贝西亚的小鼠的血清也表现出溶血活性。非感染的小鼠红细胞在与罗德西亚巴贝西亚感染的血清共孵育后被裂解。在与感染罗德西亚巴贝西亚的小鼠的溶血血清共孵育后，非感染的靶红细胞的过氧化氢酶活性受到抑制。此外，当靶红细胞在存在外源性过氧化氢酶的情况下与溶血血清孵育时，血清溶血活性被抑制。我们的研究表明，溶血血清可以下调非感染健康红细胞的抗氧化能力，可能是由于过氧化氢酶活性，从而导致溶血。
