Department of Biology, Radford University, Radford, VA 24142, United States.
Department of Neurosurgery, Pennsylvania State University, M. S. Hershey Medical Center, Hershey, PA 17033, United States.
Behav Brain Res. 2013 Jan 1;236(1):327-331. doi: 10.1016/j.bbr.2012.08.015. Epub 2012 Aug 17.
While neuropeptide Y (NPY) has been studied extensively per its pronounced role in food intake stimulation as well as its role in central pathways governing eating disorders, it has to our knowledge not been studied in polygenic models of hypo- and hyperphagia. Thus, the present study was designed to measure central NPY-associated food intake in lines of chickens that have undergone long-term genetic selection for low (LWS) or high (HWS) body weight and exhibit hypo- and hyperphagia, respectively. LWS chicks did not respond with any magnitude of altered food intake to any dose of NPY tested, while HWS chicks responded to all doses of NPY at similar magnitudes throughout the duration of observation. Both lines responded with similar increases in c-Fos immunoreactivity in the lateral hypothalamus and both divisions of the paraventricular nucleus; there were no significant line or line by treatment interactions. These data support the hypothesis that differences exist in the central NPY system of chicks from LWS and HWS lines and may provide novel insight for understanding NPY control of appetite.
虽然神经肽 Y (NPY) 因其在食物摄入刺激中的显著作用以及在中枢途径中对饮食失调的作用而被广泛研究，但据我们所知，它并未在低摄食和高摄食的多基因模型中进行研究。因此，本研究旨在测量在长期进行低体重（LWS）或高体重（HWS）遗传选择的鸡系中，中枢 NPY 相关的摄食情况，这些鸡系分别表现出低摄食和高摄食。LWS 雏鸡对测试的任何剂量的 NPY 都没有表现出任何程度的摄食改变，而 HWS 雏鸡在整个观察期间对所有剂量的 NPY 均以相似的幅度做出反应。两条线在外侧下丘脑和室旁核的两个分区中均以类似的 c-Fos 免疫反应增加；没有明显的线或线与处理的相互作用。这些数据支持这样一种假设，即 LWS 和 HWS 系小鸡的中枢 NPY 系统存在差异，这可能为理解 NPY 对食欲的控制提供新的见解。
