Noël G, Bauer N, Clavier J-B, Guihard S, Lim O, Jastaniah Z
Département universitaire de radiothérapie, centre de lutte contre le cancer Paul-Strauss, Strasbourg, France.
Cancer Radiother. 2012 Sep;16(5-6):410-7. doi: 10.1016/j.canrad.2012.07.179. Epub 2012 Aug 24.
Stereotactic radiotherapy can be delivered in one fraction or in multiple fractions schedule. It is used in benign tumours such as meningiomas, mainly localized in the base of the skull, for acoustic schwannoma and pituitary tumours. Whatever the tumour, results with the Gamma Knife(®) are the most numerous, but those obtained by linear accelerators, adapted or dedicated, are comparable. The peripheral dose is preferred to the dose delivered to the isocentre. One fraction stereotactic irradiation should be proposed in small lesions and fractionated treatment for tumours larger. Whatever the tumour, the results are satisfactory with a control rate of 90%. However, this value reflects a disparity assessment, radiological stability for meningiomas, radiological stability and preservation of useful hearing in schwannoma and radiological stability and a decrease in hormonal secretions for pituitary adenomas. Overall complication rates are low. In total, the treatment of benign lesions with stereotactic irradiation gives satisfactory results with few complications.
立体定向放射治疗可以单次分割或多次分割的方式进行。它用于治疗良性肿瘤，如主要位于颅底的脑膜瘤、听神经瘤和垂体瘤。无论何种肿瘤，使用伽玛刀（®）治疗的结果最多，但通过适配或专用的直线加速器获得的结果与之相当。外周剂量优于等中心剂量。对于小病灶应采用单次分割立体定向照射，对于较大肿瘤则采用分次治疗。无论何种肿瘤，治疗效果都令人满意，控制率达90%。然而，这个数值反映了不同的评估标准，脑膜瘤的放射学稳定性、听神经瘤的放射学稳定性及有用听力的保留、垂体腺瘤的放射学稳定性及激素分泌减少。总体并发症发生率较低。总体而言，立体定向照射治疗良性病变效果满意，并发症较少。
