光动力抗菌化疗对体外和原位生物膜的影响。
Effect of photodynamic antimicrobial chemotherapy on in vitro and in situ biofilms.
机构信息
Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil.
出版信息
Caries Res. 2012;46(6):549-54. doi: 10.1159/000341190. Epub 2012 Aug 22.
AIM
The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated.
METHODS
Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S+L+) and control (S-L-, S+L-, S-L+) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S+L+ or S-L- groups.
RESULTS
Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ.
CONCLUSION
PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.
目的
评估光动力抗菌化疗（PACT）对口腔生物膜的作用。
方法
用敏化剂（S）和/或光（L）在实验组（S+L+）和对照组（S-L-、S+L-、S-L-）中处理体外形成的生物膜。此外，21 名志愿者佩戴口腔内装置，装置两侧形成的生物膜分别称为 S+L+或 S-L-组。
结果
PACT 后，体外生物膜的活力明显下降。PACT 对原位形成的多菌种生物膜无效。
结论
PACT 对体外生物膜有效，对原位生物膜无效。
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