Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD.
Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD.
Chest. 2013 Feb 1;143(2):333-343. doi: 10.1378/chest.12-0993.
Pulmonary hypertension (PH) restricts the ability to engage in physical activity and decreases longevity. We examined the impact of aerobic exercise training on function and quality of life in patients with World Health Organization group 1 PH.
Patients were randomized to a 10-week education only (EDU) or education/exercise combined (EXE) group. The exercise program consisted of 24-30 sessions of treadmill walking for 30-45 min per session at 70% to 80% of heart rate reserve. Outcome variables included changes in 6-min walk test (6MWT) distance, time to exercise intolerance, peak work rate (WR) from a cardiopulmonary treadmill test, and quality-of-life measures, including the Short Form Health Survey, version 2 (SF-36v2) and Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR).
Data are presented as mean SD. Twenty-three women (age, 54 11 years; BMI, 31 7 kg/m 2 ) were randomized to the EDU (n 5 13) or EXE (n 5 10) groups. Following 10 weeks of intervention, patients in the EXE group demonstrated an improvement in 6MWT distance (56 45 m; P 5 .002), increased time to exercise intolerance (1.9 1.3 min; P 5 .001), and peak WR (26 23 W; P 5 .004). Additionally, the EXE group scored significantly ( P , .050) better on six of the eight scales on SF-36v2, and fi ve of the six scales on CAMPHOR. In contrast, no significant improvement was observed for any of the outcome measures following EDU. No adverse events were noted in either group.
Ten weeks of brisk treadmill walking improved 6MWT distance, cardiorespiratory function, and patient-reported quality of life in female patients with group 1 PH.
肺动脉高压（PH）限制了体力活动能力并降低了预期寿命。我们研究了有氧运动训练对 1 型 PH 患者功能和生活质量的影响。
患者被随机分为仅接受教育（EDU）或教育/运动联合组（EXE）。运动方案包括 24-30 次跑步机步行，每次 30-45 分钟，运动强度为心率储备的 70%-80%。主要终点为 6 分钟步行试验（6MWT）距离的变化、运动不耐受时间、心肺跑步机试验的峰值工作率（WR）以及生活质量评估，包括简明健康调查问卷 2 版（SF-36v2）和剑桥肺高压生活质量评估问卷（CAMPHOR）。
数据以均数标准差表示。23 名女性（年龄 54±11 岁；BMI 31±7kg/m2）被随机分配至 EDU（n=13）或 EXE（n=10）组。经过 10 周的干预，EXE 组的 6MWT 距离（56±45m）、运动不耐受时间（增加 1.9±1.3min）和峰值 WR（增加 26±23W）均显著改善（P均<.002）。此外，EXE 组在 SF-36v2 的 8 个评分中有 6 个（P<.050）显著更好，在 CAMPHOR 的 6 个评分中有 5 个（P<.050）显著更好。相比之下，EDU 组的所有结局指标均无显著改善。两组均未出现不良事件。
10 周快走跑步机训练可改善 1 型 PH 女性患者的 6MWT 距离、心肺功能和患者报告的生活质量。
