Abo Akademi University, Department of Psychology and Logopedics, Åbo, Finland.
Dement Geriatr Cogn Disord. 2012;34(2):83-9. doi: 10.1159/000342116. Epub 2012 Aug 27.
To compare the diagnostic accuracy of a computerized test, the CANTAB paired associate learning (PAL) to that of an established and validated noncomputerized test, the CERAD Wordlist Learning task in differentiating between normal aging, aMCI and AD in a cross-sectional design.
58 participants were assessed (19 with mild probable AD, 17 aMCI, 22 healthy controls).
The variables found to best discriminate between the three groups were the CANTAB PAL total errors adjusted (p < 0.0001, 81.0% of the cases correctly classified), and CERAD Wordlist Learning Delayed Recall (p < 0.0001, 77.6% of the cases correctly classified). Using both PAL total errors adjusted and Wordlist Learning Delayed Recall, 84.5% of the cases were correctly classified.
The results suggest that the CANTAB could be used for screening of AD-typical memory impairment.
比较计算机测试（CANTAB 成对关联学习 [PAL]）与已建立和验证的非计算机测试（CERAD 词汇学习任务）在横断面设计中区分正常衰老、轻度认知障碍和 AD 的诊断准确性。
评估了 58 名参与者（19 名轻度可能 AD，17 名轻度认知障碍，22 名健康对照）。
发现能够最好地区分三组的变量是 CANTAB PAL 总错误调整（p < 0.0001，81.0%的病例正确分类）和 CERAD 词汇学习延迟回忆（p < 0.0001，77.6%的病例正确分类）。同时使用 PAL 总错误调整和词汇学习延迟回忆，84.5%的病例得到正确分类。
结果表明，CANTAB 可用于 AD 典型记忆障碍的筛查。
