Huh J H, Park M S, Jeon H H
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea.
JNMA J Nepal Med Assoc. 2011 Oct-Dec;51(184):189-91.
The relationship between gastroesophageal reflux disease (GERD) and Helicobacter pylori (H. pylori) eradication is still debated. Recently, we had a patient of GERD who had developed it shortly after H. pylori eradication therapy. A 72-year-old man was diagnosed by endoscopy as suffering from severe superficial gastritis in the stomach body. A rapid urease test showed H. pylori infection. He was then started on proton pump inhibitor (PPI) based therapy for two weeks eradicating H.pylori. After completion of H. pylori eradication, he complained of a heart-burn sensation. Follow-up endoscopy showed reflux esophagitis, of grade B according to the Los Angeles classification. Since the patient had developed GERD after completion of the triple therapy, their suggests that H. pylori eradication must have triggered the development of de novo GERD after a short period of time.
胃食管反流病（GERD）与幽门螺杆菌（H. pylori）根除之间的关系仍存在争议。最近，我们有一位GERD患者，在幽门螺杆菌根除治疗后不久就患上了该病。一名72岁男性经内镜检查诊断为胃体部重度浅表性胃炎。快速尿素酶试验显示幽门螺杆菌感染。随后他开始接受基于质子泵抑制剂（PPI）的治疗，为期两周以根除幽门螺杆菌。幽门螺杆菌根除治疗完成后，他抱怨有烧心感。随访内镜检查显示为反流性食管炎，根据洛杉矶分类为B级。由于该患者在三联疗法完成后患上了GERD，这表明幽门螺杆菌根除一定在短时间内引发了新发GERD的发生。
