Gozariu L, Orbai P
Endocrinologie. 1977 Oct-Dec;15(4):263-6.
Besides their well-known actions, glucagon, ACTH, pentagastrin and insulin from the APUD series exert a direct action on the bone calcium content. Incubation with these substances of rat calvaria in vitro yields an evident stimulation of osteolysis with ACTH. Pentagastrin inhibits osteolysis. Glucagon and insulin inhibit parathormone-stimulated osteolysis, with no influence on the spontaneous one. Glucagon, resembling calcitonin, stimulates the 45Ca uptake from the incubation medium. The action of these substances completes the series of hormones influencing bone calcium metabolism, underlining possible interference actions of APUD-type hormones.
除了其广为人知的作用外，来自APUD细胞系的胰高血糖素、促肾上腺皮质激素、五肽胃泌素和胰岛素对骨钙含量具有直接作用。用这些物质在体外培养大鼠颅骨，促肾上腺皮质激素能明显刺激骨溶解。五肽胃泌素抑制骨溶解。胰高血糖素和胰岛素抑制甲状旁腺激素刺激的骨溶解，对自发性骨溶解无影响。胰高血糖素与降钙素相似，能刺激从培养液中摄取45Ca。这些物质的作用完善了影响骨钙代谢的激素系列，突出了APUD型激素可能的干扰作用。
