Division of Virology, Kawasaki City Institute of Public Health, Oshima, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan.
J Virol. 2012 Sep;86(18):10236-7. doi: 10.1128/JVI.01588-12.
A rare human G10P[8] rotavirus with a reassortment between bovine and human viruses was detected from a patient with acute gastroenteritis in Vietnam. Genetic analysis using complete coding sequences of all segments showed a genomic constellation of this virus of G10-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. Its VP7 region was genetically related to that of a bovine rotavirus derived from Australia (strain VICG10.01), whereas all other genes were identical to those of a human rotavirus derived from Australia (strain Victoria/CK00047). These results indicate a possibility that the reassortment of the rotavirus was caused by immune escape in Australia and the rotavirus was carried to Vietnam. Additionally, this finding will help further understanding the evolution of rotaviruses circulating in Vietnam.
从越南一名急性胃肠炎患者中检测到一种罕见的人源 G10P[8]轮状病毒，该病毒与牛源和人源病毒发生了重配。使用所有片段的完整编码序列进行遗传分析显示，该病毒的基因组构成是 G10-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1。其 VP7 区与源自澳大利亚的牛轮状病毒（株 VICG10.01）具有遗传关系，而所有其他基因均与人源轮状病毒（源自澳大利亚的 Victoria/CK00047 株）相同。这些结果表明，轮状病毒的重配可能是由于在澳大利亚的免疫逃避引起的，并且该轮状病毒被带到了越南。此外，这一发现将有助于进一步了解在越南流行的轮状病毒的进化。
