Matthijnssens Jelle, Ciarlet Max, Rahman Mustafizur, Attoui Houssam, Bányai Krisztián, Estes Mary K, Gentsch Jon R, Iturriza-Gómara Miren, Kirkwood Carl D, Martella Vito, Mertens Peter P C, Nakagomi Osamu, Patton John T, Ruggeri Franco M, Saif Linda J, Santos Norma, Steyer Andrej, Taniguchi Koki, Desselberger Ulrich, Van Ranst Marc
Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Arch Virol. 2008;153(8):1621-9. doi: 10.1007/s00705-008-0155-1. Epub 2008 Jul 5.
Recently, a classification system was proposed for rotaviruses in which all the 11 genomic RNA segments are used (Matthijnssens et al. in J Virol 82:3204-3219, 2008). Based on nucleotide identity cut-off percentages, different genotypes were defined for each genome segment. A nomenclature for the comparison of complete rotavirus genomes was considered in which the notations Gx-P[x]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx are used for the VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5/6 encoding genes, respectively. This classification system is an extension of the previously applied genotype-based system which made use of the rotavirus gene segments encoding VP4, VP7, VP6, and NSP4. In order to assign rotavirus strains to one of the established genotypes or a new genotype, a standard procedure is proposed in this report. As more human and animal rotavirus genomes will be completely sequenced, new genotypes for each of the 11 gene segments may be identified. A Rotavirus Classification Working Group (RCWG) including specialists in molecular virology, infectious diseases, epidemiology, and public health was formed, which can assist in the appropriate delineation of new genotypes, thus avoiding duplications and helping minimize errors. Scientists discovering a potentially new rotavirus genotype for any of the 11 gene segments are invited to send the novel sequence to the RCWG, where the sequence will be analyzed, and a new nomenclature will be advised as appropriate. The RCWG will update the list of classified strains regularly and make this accessible on a website. Close collaboration with the Study Group Reoviridae of the International Committee on the Taxonomy of Viruses will be maintained.
最近，有人提出了一种针对轮状病毒的分类系统，该系统使用了所有11个基因组RNA片段（Matthijnssens等人，《病毒学杂志》82:3204 - 3219，2008年）。根据核苷酸同一性截止百分比，为每个基因组片段定义了不同的基因型。考虑了一种用于比较完整轮状病毒基因组的命名法，其中符号Gx - P[x] - Ix - Rx - Cx - Mx - Ax - Nx - Tx - Ex - Hx分别用于VP7 - VP4 - VP6 - VP1 - VP2 - VP3 - NSP1 - NSP2 - NSP3 - NSP4 - NSP5/6编码基因。这种分类系统是先前应用的基于基因型的系统的扩展，后者使用了编码VP4、VP7、VP6和NSP4的轮状病毒基因片段。为了将轮状病毒株归入已确定的基因型之一或新的基因型，本报告提出了一个标准程序。随着更多的人类和动物轮状病毒基因组被完全测序，可能会识别出11个基因片段中每个片段的新基因型。一个包括分子病毒学、传染病、流行病学和公共卫生领域专家的轮状病毒分类工作组（RCWG）成立了，该工作组可以协助对新基因型进行适当的划分，从而避免重复并有助于尽量减少错误。发现11个基因片段中任何一个可能存在新的轮状病毒基因型的科学家被邀请将新序列发送给RCWG，在那里将对序列进行分析，并在适当时建议新的命名法。RCWG将定期更新分类菌株列表，并在网站上提供该列表。将与国际病毒分类委员会呼肠孤病毒科研究组保持密切合作。
