2009 年和 2010 年两波流感 A (H1N1) 病毒和呼吸道感染的临床差异。
Clinical differences between influenza A (H1N1) virus and respiratory infection between the two waves in 2009 and 2010.
机构信息
Unit of Infectious Diseases, General University Hospital of Alexandroupolis, Democritus University of Thrace, Komotini.
出版信息
Int J Gen Med. 2012;5:675-82. doi: 10.2147/IJGM.S34940. Epub 2012 Aug 13.
BACKGROUND
The purpose of the present retrospective study was to examine the clinical differences between patients hospitalized with H1N1 virus and those hospitalized with nonvirus respiratory tract infection in 2009 and 2010.
METHODS
Adult patient data were collected from three tertiary hospital centers. Real-time reverse transcriptase polymerase chain reaction testing was used to confirm the diagnosis. We included 106 H1N1-positive patients (52 from 2009 and 54 from 2010). These data were compared with those from 108 patients with H1N1-negative respiratory tract infection (51 patients from 2009 and 57 from 2010).
RESULTS
In 2009, the mean age was 36.4 years for H1N1-positive patients versus 46.4 years for H1N1-negative patients, and mean body mass index (BMI) was 26.4 kg/m(2) patients and 28.1 kg/m(2), respectively. In 2009, seven patients required intubation, six of whom were H1N1-positive. In 2010, the mean age was 43.8 years for H1N1-positive patients versus 60.2 years for H1N1-negative patients, and mean BMI was 32.3 kg/m(2) and 26.9 kg/m(2), respectively. In 2010, six patients required intubation, three of whom were H1N1-positive. Abnormal chest x-ray findings were found significantly more frequently in H1N1-negative patients than in H1N1-positive patients.
CONCLUSION
In comparison with 2009, H1N1-positive patients in 2010 were older, were more likely to be obese, and had more severe clinical and laboratory perturbations. However, this did not affect their outcomes. H1N1-negative patients were older in comparison with those who were H1N1-positive, and had more severe clinical and laboratory perturbations.
背景
本回顾性研究的目的是检验 2009 年和 2010 年因 H1N1 病毒住院的患者与因非病毒呼吸道感染住院的患者的临床差异。
方法
从三家三级医院中心收集成年患者数据。采用实时逆转录聚合酶链反应检测来确诊。我们纳入了 106 例 H1N1 阳性患者（2009 年 52 例，2010 年 54 例）。将这些数据与 108 例 H1N1 阴性呼吸道感染患者（2009 年 51 例，2010 年 57 例）进行比较。
结果
2009 年，H1N1 阳性患者的平均年龄为 36.4 岁，H1N1 阴性患者为 46.4 岁，平均体重指数（BMI）分别为 26.4 kg/m²和 28.1 kg/m²。2009 年，7 例患者需要插管，其中 6 例为 H1N1 阳性。2010 年，H1N1 阳性患者的平均年龄为 43.8 岁，H1N1 阴性患者为 60.2 岁，平均 BMI 分别为 32.3 kg/m²和 26.9 kg/m²。2010 年，6 例患者需要插管，其中 3 例为 H1N1 阳性。与 H1N1 阳性患者相比，H1N1 阴性患者的异常胸部 X 线表现更为常见。
结论
与 2009 年相比，2010 年 H1N1 阳性患者年龄更大，更可能肥胖，且临床表现和实验室检查更严重。然而，这并未影响他们的结局。与 H1N1 阳性患者相比，H1N1 阴性患者年龄更大，临床表现和实验室检查更严重。
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