Yun Tae Jin, Park Chang Min, Kwon Gu Jin, Woo Sung Koo, Park Seung Hoon, Choi Seung Hong, Lee Hyun Ju, Goo Jin Mo
Department of Radiology, Armed Force Byukjae Hospital, Gyeonggi-do, Korea.
Acta Radiol. 2011 May 1;52(4):410-6. doi: 10.1258/ar.2011.100411. Epub 2011 Mar 9.
Since the first outbreak caused by the pandemic H1N1 2009 influenza in Mexico, the virus has spread widely across the world with meaningful morbidity and mortality. However, there are few data on the comparative investigations to assess the clinical and radiological features between the H1N1 patient and non-H1N1 patients.
To assess the clinical and radiological features of patients infected by the pandemic H1N1 2009 flu virus at their initial presentation and to compare them with contemporaneous non-H1N1 patients with acute febrile respiratory illness.
This retrospective study was approved by the ethics committee of the Armed Forces Medical Command, South Korea. From August to September 2009, 337 consecutive patients presented with an acute febrile respiratory illness in a tertiary military hospital. Reverse-transcriptase polymerase-chain-reaction tests were performed in 62 of these patients under the impression of H1N1 infection. Clinical and radiological features at their initial presentation were described for the H1N1 group (n = 35) and non-H1N1 group (n = 27) and compared between the two groups.
Increased C-reactive protein level (97%) without leukocytosis (9%) or increased erythrocyte sedimentation rate (0%) was common in the H1N1 group at their initial presentation. On chest radiographs, 12 of 35 (34%) H1N1 patients had abnormal findings; nodules in 10 patients (83%) and consolidations in two (17%). Of the 28 H1N1 patients who underwent thin-section CT 16 patients (57%) showed abnormal findings; ground-glass opacities (GGOs) in 15 (94%), and nodules in 13 (81%). However, there were no significant differences between the H1N1 group and non-H1N1 group in terms of symptoms, laboratory results, or radiological findings (P > 0.05).
Patients with H1N1 infection show consistent clinical and radiological features at their initial presentation, however, clinical and radiological features of the H1N1 group are not significantly different from those of the non-H1N1 group.
自2009年甲型H1N1流感大流行在墨西哥首次爆发以来，该病毒已在全球广泛传播，导致了显著的发病率和死亡率。然而，关于评估甲型H1N1流感患者与非甲型H1N1流感患者临床及影像学特征的对比研究数据较少。
评估2009年甲型H1N1流感病毒感染患者初诊时的临床及影像学特征，并将其与同期患有急性发热性呼吸道疾病的非甲型H1N1流感患者进行比较。
本回顾性研究经韩国武装部队医疗司令部伦理委员会批准。2009年8月至9月期间，一家三级军事医院连续收治了337例急性发热性呼吸道疾病患者。其中62例疑似甲型H1N1流感感染的患者接受了逆转录聚合酶链反应检测。对甲型H1N1流感组（n = 35）和非甲型H1N1流感组（n = 27）患者初诊时的临床及影像学特征进行描述，并在两组之间进行比较。
甲型H1N1流感组患者初诊时常见C反应蛋白水平升高（97%），白细胞计数无升高（9%）或红细胞沉降率无升高（0%）。胸部X线片显示，35例甲型H1N1流感患者中有12例（34%）有异常表现；10例（83%）出现结节，2例（17%）出现实变。在接受薄层CT检查的28例甲型H1N1流感患者中，16例（57%）有异常表现；15例（94%）出现磨玻璃影，13例（81%）出现结节。然而，甲型H1N1流感组与非甲型H1N1流感组在症状、实验室检查结果或影像学表现方面无显著差异（P > 0.05）。
甲型H1N1流感感染患者初诊时表现出一致的临床及影像学特征，然而，甲型H1N1流感组的临床及影像学特征与非甲型H1N1流感组无显著差异。
