沉香叶中的一种新型一氧化氮生成抑制剂——沉香黄苷
Aquisiflavoside, a new nitric oxide production inhibitor from the leaves of Aquilaria sinensis.
作者信息
Yang Xin-Bao, Feng Jie, Yang Xiu-Wei, Zhao Bo, Liu Jian-Xun
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
出版信息
J Asian Nat Prod Res. 2012;14(9):867-72. doi: 10.1080/10286020.2012.701209. Epub 2012 Aug 28.
A new flavonoid glycoside, named aquisiflavoside, was isolated from the leaves of Aquilaria sinensis (Lour.) Gilg, and its structure was elucidated by spectroscopic analyses. Aquisiflavoside was evaluated for the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited a potent inhibitory activity against NO production in a dose-dependent manner with an IC(50) value of 34.95 μM.
从白木香叶中分离得到一种新的黄酮苷，命名为沉香黄酮苷，并通过光谱分析对其结构进行了阐明。在巨噬细胞系RAW 264.7中，对沉香黄酮苷抑制脂多糖诱导的一氧化氮（NO）生成的作用进行了评估，结果显示其对NO生成具有显著的剂量依赖性抑制活性，IC50值为34.95 μM。
Zotero 插件