两种具有抗炎活性的来自香鳞毛蕨的新糖苷。

Two new glycosides from Dryopteris fragrans with anti-inflammatory activities.

作者信息

Peng Bing, Bai Rui-Feng, Li Ping, Han Xu-Yang, Wang Hong, Zhu Chong-Chong, Zeng Zu-Ping, Chai Xing-Yun

机构信息

a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.

b Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029 , China.

出版信息

J Asian Nat Prod Res. 2016;18(1):59-64. doi: 10.1080/10286020.2015.1121853. Epub 2015 Dec 24.

DOI:10.1080/10286020.2015.1121853

PMID:26700189

Abstract

Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1-3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 μM, respectively.

摘要

对香鳞毛蕨水提取物进行植物化学研究，分离得到一个新的色酮糖苷，香鳞毛蕨色酮C（1）和一个新的香豆素糖苷，香鳞毛蕨香豆素A（2），以及一个已知的波叶大黄苷A（3）。通过一维和二维核磁共振、高分辨质谱和化学分析相结合的方法阐明了它们的结构。化合物1-3对脂多糖诱导的RAW 264.7巨噬细胞中一氧化氮的产生具有抑制作用，其半数抑制浓度（IC50）值分别为45.8、65.8和49.8μM。