Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Ministry of Education & National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Molecules. 2018 Feb 7;23(2):342. doi: 10.3390/molecules23020342.
Agarwood, a highly precious non-timber fragrant wood of spp. (Thymelaeaceae), has been widely used in traditional medicine, religious rites, and cultural activities. Due to the inflated demanding and depleted natural resources, the yields of agarwood collected from the wild are shrinking, and the price is constantly rising, which restricts agarwood scientific research and wide application. With the sustainable planting and management of agarwood applied, and especially the artificial-inducing methods being used in China and Southeast Asian countries, agarwood yields are increasing, and the price is becoming more reasonable. Under this condition, illuminating the scientific nature of traditional agarwood application and developing new products and drugs from agarwood have become vitally important. Recently, the phytochemical investigations have achieved fruitful results, and more than 300 compounds have been isolated, including numerous new compounds that might be the characteristic constituents with physiological action. However, no one has focused on the new compounds and presented a summary until now. Alongside phytochemical advances, bioactivity screening and pharmacological investigation have also made a certain progress. Therefore, this review discussed the new compounds isolated after 2010, and summarized the pharmacological progress on agarwood and plants.
沉香，瑞香科 属（Thymelaeaceae）的一种高度珍贵的非木材香料，已广泛应用于传统医学、宗教仪式和文化活动中。由于需求膨胀和自然资源枯竭，野生沉香的产量正在减少，价格不断上涨，这限制了沉香的科学研究和广泛应用。随着沉香的可持续种植和管理，特别是在中国和东南亚国家应用的人工诱导方法，沉香的产量正在增加，价格也变得更加合理。在这种情况下，阐明传统沉香应用的科学性质，开发沉香的新产品和药物变得至关重要。最近，植物化学研究取得了丰硕的成果，已经分离出 300 多种化合物，包括许多可能具有生理作用的特征成分的新化合物。然而，到目前为止，还没有人关注这些新化合物，并对其进行总结。除了植物化学方面的进展，生物活性筛选和药理学研究也取得了一定的进展。因此，本综述讨论了 2010 年后分离出的新化合物，并总结了沉香和 属植物的药理学进展。
