Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK.
Vector Borne Zoonotic Dis. 2012 Sep;12(9):800-4. doi: 10.1089/vbz.2011.0776. Epub 2012 Aug 27.
Crimean-Congo hemorrhagic fever (CCHF) is a virus transmitted predominantly by ticks. However, contact with infected body fluids or tissues can result in animal-to-human or human-to-human transmission. Numbers of CCHF cases appear to be increasing, especially in Europe. We reviewed cases admitted to a tertiary referral unit in Kosova with suspected CCHF in 2008 and 2009, and looked at a smaller number of specimens which were sent to the Health Protection Agency, Porton Down, U.K., in further detail. The clinical features of cases admitted with suspected CCHF infection were assessed in more detail, and these are the focus of this article. Between 2008 and 2009, the numbers of patients admitted for suspected CCHF infection increased. Of the samples received in Porton Down, CCHF virus was detected in urine samples, and these patients were found to have prolonged viremia. The detection of CCHF in urine, as well as the prolonged viremias seen, are important for clinicians to know, as they may have public health implications with regard to the risk of infection, as well as provide insights into the biology and pathophysiology of infection. Further studies are required regarding the pathogenesis of this virus.
克里米亚-刚果出血热（CCHF）主要由蜱传播。然而，接触受感染的体液或组织也可能导致动物与人或人与人之间的传播。CCHF 病例的数量似乎在增加，尤其是在欧洲。我们回顾了 2008 年和 2009 年在科索沃一家三级转诊医院收治的疑似 CCHF 病例，并进一步详细研究了送往英国波顿唐的卫生保护局的少数标本。我们更详细地评估了疑似 CCHF 感染入院病例的临床特征，这是本文的重点。2008 年至 2009 年，因疑似 CCHF 感染而住院的患者人数增加。在波顿唐收到的样本中，检测到了尿样中的 CCHF 病毒，这些患者的病毒血症持续时间延长。尿液中检测到 CCHF 以及观察到的病毒血症延长，对临床医生来说很重要，因为这可能对感染风险的公共卫生具有影响，并深入了解感染的生物学和病理生理学。需要进一步研究这种病毒的发病机制。
