Division of Pediatric Endocrinology, Metabolism and Diabetes, Department of Pediatrics, The Clinical Research Center of The Ohio State University College of Medicine and Public Health, Columbus, OH 43205, USA.
Pediatr Diabetes. 2012 Dec;13(8):607-10. doi: 10.1111/j.1399-5448.2012.00882.x. Epub 2012 Aug 28.
To determine whether acute ascorbic acid infusions alter the effect of hyperglycemia on endothelial function in adolescents with type 1 diabetes.
The forearm blood flow (FBF) reactive hyperemic response to 5 min of upper arm occlusion was studied in eight adolescents with type 1 diabetes during euglycemic and hyperglycemic insulin clamp (40 mU/m2/min) with and without ascorbic acid infusion (3 mg/min).
The ratio of post- to preocclusion FBF decreased during hyperglycemia without ascorbic acid (p = 0.013), but did not change during hyperglycemia with ascorbic acid. The changes during hyperglycemia were different between the two studies (p = 0.038). Similar results were found when the percent change in forearm vascular resistance following occlusion was assessed.
These results indicate that antioxidant treatment with ascorbic acid blocks acute hyperglycemic impairment of endothelial function in adolescents with type 1 diabetes.
确定急性抗坏血酸输注是否会改变 1 型糖尿病青少年高血糖对内皮功能的影响。
在 8 名 1 型糖尿病青少年中，通过在上臂夹闭 5 分钟期间测量前臂血流（FBF）反应性充血反应，研究了在给予和不给予抗坏血酸输注（3mg/min）的情况下，进行正常血糖和高血糖胰岛素钳夹（40mU/m2/min）时的内皮功能。
在没有抗坏血酸的情况下，高血糖期间后至闭塞前 FBF 的比值降低（p=0.013），但在有抗坏血酸的情况下高血糖期间没有改变。在两项研究中，高血糖期间的变化不同（p=0.038）。当评估闭塞后前臂血管阻力的百分比变化时，也得到了类似的结果。
这些结果表明，用抗坏血酸进行抗氧化治疗可阻止 1 型糖尿病青少年急性高血糖对内皮功能的损害。
