Fukunishi K, Sawada K, Kashima M, Sakata-Haga H, Fukuzaki K, Fukui Y
Department of Anatomy and Developmental Neurobiology, University of Tokushima Graduate School Institute of Health Biosciences, Tokushima 770-8503, Japan.
Anat Embryol (Berl). 2006 Nov;211(6):757-64. doi: 10.1007/s00429-006-0136-7. Epub 2006 Oct 28.
This study aimed to clarify the development of sulci and gyri on the external surface of the cerebrum of cynomolgus monkeys. Sulcus formation began with the appearance of the lateral fissure on embryonic day (ED) 70, followed by delineations of four cerebral lobes by the emergence of the parietooccipital sulcus, central sulcus, and preoccipital notch on EDs 80-90. The following primary sulci were then visible until ED 120: the superior temporal sulcus on ED 90; the intraparietal sulcus, lunate sulcus, inferior occipital sulcus, and arcuate sulcus on ED 100; and the principle sulcus on ED 110; the occipitotemporal sulcus, anterior middle temporal sulcus, and superior postcentral dimple on ED 120. These sulci demarcated the superior temporal gyrus on ED 90, the precentral gyrus, supramarginal gyrus, and angular gyrus on ED 100, and the inferior and middle temporal gyri, postocentral gyrus, superior parietal lobule, superior, middle and inferior frontal gyri, and inferior occipital gyrus on ED 120. Except for the intermediate and lateral orbitofrontal sulci, the sulci that appeared on ED 130 and thereafter were not related to the gyrus demarcations. Intriguingly, the brain markedly gained weight on EDs 100 and 120, corresponding to the embryonic ages when almost all gyri were visible. The results suggest that a rapid growth of the cerebrum involves convolutions of the gyri by a regular sequence of the sulcus formation in cynomolgus monkeys. This study further provides a standard of reference for normal development in the cerebral cortical morphology of cynomolgus monkeys.
本研究旨在阐明食蟹猴大脑外表面脑沟和脑回的发育情况。脑沟形成始于胚胎第70天外侧裂的出现，随后在第80 - 90天，顶枕沟、中央沟和枕前切迹的出现勾勒出四个脑叶。接下来直到胚胎第120天可见以下主要脑沟：第90天的颞上沟；第100天的顶内沟、月状沟、枕下沟和弓状沟；第110天的主沟；第120天的枕颞沟、颞中前沟和中央后上凹。这些脑沟在第90天划分出颞上回，在第100天划分出中央前回、缘上回和角回，在第120天划分出颞下回和颞中回、中央后回、顶上小叶、额上回、额中回和额下回以及枕下回。除眶额中间沟和外侧沟外，在第130天及之后出现的脑沟与脑回划分无关。有趣的是，大脑在第100天和第120天显著增重，这与几乎所有脑回都可见的胚胎年龄相对应。结果表明，食蟹猴大脑的快速生长涉及脑回通过脑沟形成的规则序列进行卷曲。本研究进一步为食蟹猴大脑皮质形态的正常发育提供了参考标准。
