Gehanno P, Andrews J M, Ichou F, Sultan E, Lenfant B
ENT Department, Hôpital Bichat, Paris, France.
J Antimicrob Chemother. 1990 Dec;26 Suppl E:47-51. doi: 10.1093/jac/26.suppl_e.47.
Seventeen patients undergoing tonsillectomy received cefpodoxime proxetil orally in a dose equivalent to 100 mg cefpodoxime 4, 7 or 12 h before operation. Plasma and tonsillar tissue concentrations of cefpodoxime were assayed by a microbiological method. Tonsillar tissue concentrations after 4 and 7 h were 0.24 and 0.09 mg/kg respectively--being 23% of the plasma concentration. The tonsillar tissue concentration after 12 h was less than 0.06 mg/kg. As the MIC for Streptococcus pyogenes is less than 0.06 mg/l, cefpodoxime proxetil may be of value in acute tonsillitis.
17例接受扁桃体切除术的患者在手术前4、7或12小时口服头孢泊肟酯，剂量相当于100mg头孢泊肟。采用微生物学方法测定血浆和扁桃体组织中头孢泊肟的浓度。4小时和7小时后的扁桃体组织浓度分别为0.24mg/kg和0.09mg/kg，分别为血浆浓度的23%。12小时后的扁桃体组织浓度低于0.06mg/kg。由于化脓性链球菌的最低抑菌浓度小于0.06mg/l，头孢泊肟酯可能对急性扁桃体炎有价值。
