Dumont R, Guetat F, Andrews J M, Sultan E, Lenfant B
Department of Pneumology, Regional Hospital Centre, Bourg en Bresse, France.
J Antimicrob Chemother. 1990 Dec;26 Suppl E:41-6. doi: 10.1093/jac/26.suppl_e.41.
Eighteen patients of either sex with pleural effusions underwent aspiration 3, 6 or 12 h after receiving a single oral dose of cefpodoxime proxetil equivalent to 200 mg cefpodoxime. The mean concentrations of cefpodoxime in pleural fluid were, respectively, 0.62, 1.84 and 0.78 mg/l for these three time intervals, the corresponding ratios between pleural fluid and plasma concentrations being 0.24, 0.67 and 1.07. The findings indicate that there is good penetration of cefpodoxime into pleural fluid. Concentrations between 3 and 12 h after dosing were equal to or above the MIC90 for most of the organisms commonly found in lower respiratory tract infections.
18例有胸腔积液的患者，无论男女，在单次口服相当于200mg头孢泊肟的头孢泊肟酯后3、6或12小时接受胸腔穿刺。在这三个时间间隔内，胸腔积液中头孢泊肟的平均浓度分别为0.62、1.84和0.78mg/L，胸腔积液与血浆浓度的相应比值分别为0.24、0.67和1.07。这些结果表明头孢泊肟能很好地渗透到胸腔积液中。给药后3至12小时的浓度等于或高于下呼吸道感染中常见的大多数病原体的MIC90。
