慢性阻塞性气道疾病急性加重期的治疗——阿莫西林与环丙沙星的比较

Treatment of acute exacerbations of chronic obstructive airways disease--a comparison of amoxycillin and ciprofloxacin.

作者信息

Basran G S, Joseph J, Abbas A M, Hughes C, Tillotson G S

机构信息

Rotherham District General Hospital, Rotherham, UK.

出版信息

J Antimicrob Chemother. 1990 Dec;26 Suppl F:19-24. doi: 10.1093/jac/26.suppl_f.19.

DOI:10.1093/jac/26.suppl_f.19

PMID:2292540

Abstract

Ciprofloxacin and amoxycillin were compared in the treatment of acute exacerbations of chronic obstructive airways disease. One hundred and forty patients were evaluable for overall outcome: 60 patients' sputum specimens yielded positive bacteriological cultures. The predominant pathogens were Haemophilus influenzae (43.3%) and Streptococcus pneumoniae (25.0%). Both regimens were safe and produced few adverse effects. An independent observer judged ciprofloxacin to produce a 91.8% success rate (complete success 21.9%; partial success 69.9%) whilst a 73.1% rate (complete success 10.4%; partial success 62.7%) was seen with amoxycillin.

摘要

对环丙沙星和阿莫西林治疗慢性阻塞性气道疾病急性加重期的疗效进行了比较。140例患者可对总体结果进行评估：60例患者的痰标本细菌培养呈阳性。主要病原体为流感嗜血杆菌（43.3%）和肺炎链球菌（25.0%）。两种治疗方案均安全，不良反应少。一名独立观察者判定环丙沙星的成功率为91.8%（完全成功21.9%；部分成功69.9%），而阿莫西林的成功率为73.1%（完全成功10.4%；部分成功62.7%）。