Crean School of Health and Life Sciences, Chapman University, One University Drive, Orange, CA 92866, USA.
Dev Sci. 2012 Sep;15(5):601-10. doi: 10.1111/j.1467-7687.2012.01159.x. Epub 2012 Jun 27.
Maternal cortisol levels (at 15, 19, 25, 31 and 37 weeks' gestation) and fetal movement response to vibroacoustic stimulation (VAS; at 25, 31 and 37 weeks) were assessed in 190 mother-fetus pairs. Fetuses showed a response to the VAS at 25 weeks and there was evidence of increasing maturation in the response at 31 and 37 weeks. Early elevations in cortisol predicted a failure to respond to the VAS at 25 weeks and later elevations in cortisol were associated with a larger response among fetuses when assessed near term. The associations between cortisol and VAS emerged earlier and were more apparent among female fetuses than among the males. The findings provide support for the role of prenatal glucocorticoids in shaping human fetal CNS development.
对 190 对母婴进行了母体皮质醇水平（在妊娠 15、19、25、31 和 37 周时）和胎儿对振动声刺激的运动反应（在 25、31 和 37 周时）的评估。胎儿在 25 周时对 VAS 有反应，并且在 31 周和 37 周时反应有证据表明成熟度增加。皮质醇的早期升高预示着胎儿在 25 周时无法对 VAS 做出反应，而皮质醇的后期升高与胎儿在接近足月时的更大反应有关。皮质醇与 VAS 之间的关联出现得更早，在女性胎儿中比男性胎儿中更为明显。这些发现为产前糖皮质激素在塑造人类胎儿中枢神经系统发育中的作用提供了支持。
