Discipline of Medicine, School of Medicine, University of Adelaide - Modbury Hospital, Modbury, South Australia, Australia.
Int J Evid Based Healthc. 2012 Sep;10(3):222-6. doi: 10.1111/j.1744-1609.2012.00279.x.
Osteoarthritis is a chronic disease with a major impact on quality of life for a large proportion of the population. It is a disease for which to date there has been no disease-modifying therapy identified. As a result of its physiological role in articular cartilage, glucosamine sulphate has been postulated as a treatment for osteoarthritis. Claims have included symptomatic relief and even reduction in the rate of disease progression. Despite promising in vitro studies, however, the role of glucosamine sulphate in the management of osteoarthritis remains unclear. Studies addressing this issue have generated a wide range of conclusions, and these are discussed here. Methodological issues need to be addressed in order to gauge whether there is true benefit. On current evidence, it would appear that the benefits of dietary supplementation with glucosamine sulphate are limited to mild symptomatic relief, while a disease-modifying agent for this disease remains elusive.
骨关节炎是一种慢性病，对很大一部分人群的生活质量有重大影响。这种疾病至今尚未发现有疗效确切的药物。鉴于其在关节软骨中的生理作用，硫酸氨基葡萄糖被认为是一种治疗骨关节炎的药物。其功效包括缓解症状，甚至减缓疾病进展速度。然而，尽管体外研究结果很有前景，但硫酸氨基葡萄糖在骨关节炎治疗中的作用仍不明确。针对这一问题的研究得出了广泛的结论，本文对这些结论进行了讨论。为了评估是否存在真正的益处，需要解决方法学问题。根据目前的证据，硫酸氨基葡萄糖的饮食补充似乎仅限于轻度症状缓解，而这种疾病的疗效确切的药物仍难以捉摸。
