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Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia.

作者信息

Kano S, Colantuoni C, Han F, Zhou Z, Yuan Q, Wilson A, Takayanagi Y, Lee Y, Rapoport J, Eaton W, Cascella N, Ji H, Goldman D, Sawa A

出版信息

Mol Psychiatry. 2013 Jul;18(7):740-2. doi: 10.1038/mp.2012.120. Epub 2012 Aug 28.

DOI:10.1038/mp.2012.120
PMID:22925834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3582810/
Abstract
摘要

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Substance-specific and shared transcription and epigenetic changes in the human hippocampus chronically exposed to cocaine and alcohol.长期接触可卡因和酒精后人类海马体内物质特异性和共享转录及表观遗传变化。
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6626-31. doi: 10.1073/pnas.1018514108. Epub 2011 Apr 4.
2
Computational analysis of ChIP-seq data.染色质免疫沉淀测序（ChIP-seq）数据的计算分析
Methods Mol Biol. 2010;674:143-59. doi: 10.1007/978-1-60761-854-6_9.
3
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex.前额叶皮层中神经元 H3K4me3 表观基因组的发育调控和个体差异。
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8824-9. doi: 10.1073/pnas.1001702107. Epub 2010 Apr 26.
4
Neuronal biomarkers from patients with mental illnesses: a novel method through nasal biopsy combined with laser-captured microdissection.精神疾病患者的神经元生物标志物：一种通过鼻腔活检结合激光捕获显微切割的新方法。
Mol Psychiatry. 2010 Mar;15(3):231-2. doi: 10.1038/mp.2009.73.
5
Epigenetic mechanisms that underpin metabolic and cardiovascular diseases.构成代谢和心血管疾病基础的表观遗传机制。
Nat Rev Endocrinol. 2009 Jul;5(7):401-8. doi: 10.1038/nrendo.2009.102. Epub 2009 Jun 2.
6
Redox dysregulation, neurodevelopment, and schizophrenia.氧化还原调节异常、神经发育与精神分裂症
Curr Opin Neurobiol. 2009 Apr;19(2):220-30. doi: 10.1016/j.conb.2009.05.001. Epub 2009 May 27.
7
An integrated software system for analyzing ChIP-chip and ChIP-seq data.一个用于分析染色质免疫沉淀芯片（ChIP-chip）和染色质免疫沉淀测序（ChIP-seq）数据的集成软件系统。
Nat Biotechnol. 2008 Nov;26(11):1293-300. doi: 10.1038/nbt.1505. Epub 2008 Nov 2.
8
Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters.精神分裂症中的前额叶功能障碍涉及混合谱系白血病1调控的γ-氨基丁酸能基因启动子处的组蛋白甲基化。
J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
9
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.多能细胞和谱系定向细胞中染色质状态的全基因组图谱。
Nature. 2007 Aug 2;448(7153):553-60. doi: 10.1038/nature06008. Epub 2007 Jul 1.
10
Phenotypic plasticity and the epigenetics of human disease.表型可塑性与人类疾病的表观遗传学
Nature. 2007 May 24;447(7143):433-40. doi: 10.1038/nature05919.